Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25675
Title: Age-related differences in response regulation as revealed by functional MRI
Authors: Lee, TMC
Zhang, JX
Chan, CCH 
Yuen, KSL
Chu, LW
Cheung, RTF
Chan, YS
Fox, PT
Gao, JH
Keywords: Ageing
Functional magnetic resonance imaging
Habitual response
Inhibition
Response regulation
Issue Date: 2006
Publisher: Elsevier
Source: Brain research, 2006, v. 1076, no. 1, p. 171-176 How to cite?
Journal: Brain research 
Abstract: This fMRI study studied age-related differences in neural activities during response regulation. Twenty-one male participants from two age groups, a younger group and an older group (mean ages: 29.9 and 65.2 years, respectively), were scanned while performing a task with response compatibility manipulation. They were presented with a sequence of arrowheads that pointed either upward or downward. In the "Response Compatible" condition, they were required to press an up or a down button consistent with the direction of the arrowhead. In the "Response Incompatible" condition, they were required to press the button opposite to the arrowhead direction so that an upward arrow should elicit a down response, and vice versa. Findings showed age-related differences in response regulation in several brain regions, including the right frontal, the right cingulate, and the left inferior parietal cortexes. The findings suggested a higher level of neural activity in the right prefrontal and left inferior parietal regions during response regulation for the older adults than for the younger adults.
URI: http://hdl.handle.net/10397/25675
ISSN: 0006-8993
EISSN: 1872-6240
DOI: 10.1016/j.brainres.2005.12.124
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