Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25391
Title: SON is a spliceosome-associated factor required for mitotic progression
Authors: Huen, MSY
Sy, SMH
Leung, KM
Ching, YP
Tipoe, GL
Man, C
Dong, S
Chen, J
Keywords: MAD2
Mitosis
SON
Splicing factor
Issue Date: 2010
Publisher: Landes Bioscience
Source: Cell cycle, 2010, v. 9, no. 13, p. 2679-2685 How to cite?
Journal: Cell Cycle 
Abstract: The eukaryotic RNA splicing machinery is dedicated to the daunting task of excising intronic sequences on the many nascent RNA transcripts in a cell, and in doing so facilitates proper translation of its transcriptome. Notably, emerging evidence suggests that RNA splicing may also play direct roles in maintaining genome stability. Here we report the identification of the RNA/DNA-binding protein SON as a component of spliceosome that plays pleiotropic roles during mitotic progression. We found that SON is essential for cell proliferation, and that its inactivation triggers a MAD2-dependent mitotic delay. Moreover, SON deficiency is accompanied by defective chromosome congression, compromised chromosome segregation and cytokinesis, which in turn contributes to cellular aneuploidy and cell death. In summary, our study uncovers a specific link between SON and mitosis, and highlights the potential of RNA processing as additional regulatory mechanisms that govern cell proliferation and division.
URI: http://hdl.handle.net/10397/25391
DOI: 10.4161/cc.9.13.12151
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

14
Last Week
0
Last month
0
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

13
Last Week
0
Last month
0
Citations as of Aug 20, 2017

Page view(s)

33
Last Week
0
Last month
Checked on Aug 20, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.