Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25218
Title: Fabrication and characterization of poly-d-l-lactide/nano-hydroxyapatite composite scaffolds with poly (ethylene glycol) coating and dexamethasone releasing
Authors: Chen, L
Tang, CY 
Chen, DZ
Wong, CT
Tsui, CP 
Keywords: B. Porosity/Voids
B. Surface treatments
E. Casting
Issue Date: 2011
Publisher: Pergamon Press
Source: Composites science and technology, 2011, v. 71, no. 16, p. 1842-1849 How to cite?
Journal: Composites science and technology 
Abstract: The control of pore size and structure, drug release capacity, and biodegradation of scaffolds is of importance for bone tissue engineering. In this study, a technique combining polymer coagulation, cold compression molding, salt particulate leaching and drug coating method was developed to fabricate poly (ethylene glycol)/dexamethasone coated porous poly-d-l-lactide/nano-hydroxyapatite (PDLLA/nano-HAp) scaffolds. These scaffolds possess homogenous pore networks with high porosity (66-82%) and controllable pore size (200-300μm). The compressive moduli and strength of the scaffolds after incorporation of nano-HAp were improved by 50% and 20%, respectively. The surface hydrophilicity of the scaffold was significantly improved by poly (ethylene glycol)/dexamethasone coating and nano-HAp addition, leading to a higher initial drug loading amount. The results showed that the drug release behavior of the scaffolds after 35-day immersion in water could be adjusted by varying the porosity level and by incorporation of 20 wt% of nano-HAp.
URI: http://hdl.handle.net/10397/25218
ISSN: 0266-3538
EISSN: 1879-1050
DOI: 10.1016/j.compscitech.2011.08.015
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