Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25002
Title: Highly enantioselective catalytic alkynylation of ketones - A convenient approach to optically active propargylic alcohols
Authors: Lu, G
Li, X
Li, YM
Kwong, FY 
Chan, ASC
Keywords: Alkynylation
Asymmetric catalysis
Camphorsulfonamides
Organozinc compounds
Issue Date: 2006
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2006, v. 348, no. 14, p. 1926-1933 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: The development of highly enantioselective catalysts involving Cu(OTf) 2 and chiral camphorsulfonamides for the alkynylation of ketone is described. The influences of Lewis acids, reaction conditions and chiral ligands on the outcome of the reaction are discussed. The best enantioselectivity (up to 97% ee) was obtained in the alkynylation of 2′-chloroacetophenone. The scope of the reaction is also examined.
URI: http://hdl.handle.net/10397/25002
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.200606078
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