Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24990
Title: Comparison of aminolevulinic acid and its methyl ester mediated photocytotoxicity on human nasopharyngeal carcinoma cells
Authors: Yow, CMN
Wu, RWK
Huang, Z
Keywords: Aminolevulinic acid
methylaminolevulinate
nasopharyngeal carcinoma
photodynamic therapy
Issue Date: 2012
Publisher: World Scientific Publ Co Pte Ltd
Source: Journal of innovative optical health sciences, 2012, v. 5, no. 2, 1250007 How to cite?
Journal: Journal of Innovative Optical Health Sciences 
Abstract: Nasopharyngeal carcinoma (NPC) is a prevalent cancer in some areas of southern Asia. To explore the potential of photodynamic therapy (PDT) for the treatment of NPC, a small molecule prodrug 5-aminolevulinic acid (ALA) and its methyl ester (MAL) mediated PDT was studied in vitro. The results showed that human NPC cells were sensitive to both ALA- and MAL-mediated PDT. However, ALA was more effective than MAL, possiblly due to a higher efficiency of ALA on producing endogenous protoporphyrin (PpIX) in NPC cells. Neither ALA nor MAL caused any significant genotoxicity. The ALA-based PDT might be a useful modality in the treatment of NPC.
URI: http://hdl.handle.net/10397/24990
DOI: 10.1142/S1793545812500071
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