Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24923
Title: A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer
Authors: Osanai, K
Landis-Piwowar, KR
Dou, QP
Chan, TH
Keywords: Green tea polyphenols
Epigallocatechin-3-gallate
Para-aminobenzoic acid
Pro-drug
Proteasome
Apoptosis
Issue Date: 2007
Publisher: Pergamon-Elsevier Science Ltd
Source: Bioorganic & medicinal chemistry, 2007, v. 15, no. 15, p. 5076-5082 How to cite?
Journal: Bioorganic & Medicinal Chemistry 
Abstract: Analogs of (-)-EGCG containing a para-amino group on the D-ring in place of the hydroxyl groups have been synthesized and their proteasome inhibitory activities were studied. We found that, the O-acetylated (-)-EGCG analogs possessing a p-NH2 or p-NHBoc (Boc; tert-butoxycarbonyl) D-ring (5 and 7) act as novel tumor cellular proteasome inhibitors and apoptosis inducers with potency similar to natural (-)-EGCG and similar to (-)-EGCG peracetate. These data suggest that the acetylated amino-GTP analogs have the potential to be developed into novel anticancer agents.
URI: http://hdl.handle.net/10397/24923
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2007.05.041
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