Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24747
DC FieldValueLanguage
dc.contributorDepartment of Health Technology and Informatics-
dc.creatorYang, M-
dc.creatorLim, CC-
dc.creatorLiao, R-
dc.creatorZhang, X-
dc.date.accessioned2015-06-23T09:15:34Z-
dc.date.available2015-06-23T09:15:34Z-
dc.identifier.issn1057-7157-
dc.identifier.urihttp://hdl.handle.net/10397/24747-
dc.language.isoenen_US
dc.subjectAnisotropyen_US
dc.subjectCardiac myocytesen_US
dc.subjectDielectrophoresis (DEP)en_US
dc.subjectElectro-orientationen_US
dc.titleOriented and vectorial patterning of cardiac myocytes using a microfluidic dielectrophoresis chip - Towards engineered cardiac tissue with controlled macroscopic anisotropyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage1483-
dc.identifier.epage1491-
dc.identifier.volume15-
dc.identifier.issue6-
dc.identifier.doi10.1109/JMEMS.2006.883530-
dcterms.abstractRecently, the ability to create engineered heart tissues with a preferential cell orientation has gained much interest. Here, we present a novel method to construct a cardiac myocyte tissue-like structure using a combination of dielectrophoresis and electro-orientation via a microfluidic chip. The device includes a top home-made silicone chamber containing microfluidic channels and bottom integrated microelectrodes which are patterned on a glass slide to generate dielectrophoresis force and orientation torque. Using the interdigitated-castellated microelectrodes, the induction of a mutually attractive dielectrophoretic force between cardiac myocytes can lead to cells moving close to each other and forming a tissue-like structure with orientation along the alternating current (ac) electric field between the microelectrode gaps. Both experiments and analysis indicate that a large orientation torque and force can be achieved by choosing an optimal frequency around 2 MHz and decreasing the conductivity of medium to a relatively low level. Finally, electromechanical experiments and biopolar impedance measurements were performed to demonstrate the structural and functional anisotropy of electro-oriented structure.-
dcterms.bibliographicCitationJournal of microelectromechanical systems, 2006, v. 15, no. 6, p. 1483-1491-
dcterms.isPartOfJournal of Microelectromechanical Systems-
dcterms.issued2006-
dc.identifier.scopus2-s2.0-33845526761-
dc.identifier.rosgroupidr34207-
dc.description.ros2006-2007 > Academic research: refereed > Publication in refereed journal-
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