Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24739
Title: A mild and efficient palladium-catalyzed cyanation of aryl chlorides with K4[Fe(CN)6]
Authors: Yeung, PY
So, CM
Lau, CP
Kwong, FY 
Issue Date: 2011
Publisher: American Chemical Society
Source: Organic letters, 2011, v. 13, no. 4, p. 648-651 How to cite?
Journal: Organic letters 
Abstract: An efficient palladium-catalyzed cyanation of aryl chlorides is established. In the presence of a highly effective Pd/CM-phos catalyst, cyanation of aryl chlorides proceeds at 70 °C in general, which is the mildest reaction temperature achieved so far for this process. Common functional groups such as keto, aldehyde, ester, nitrile and-NH2, and heterocyclic coupling partners including N-H indoles are well tolerated. Moreover, a sterically hindered nonactivated ortho,ortho-disubstituted electrophile is shown to be a feasible coupling partner in cyanation.
URI: http://hdl.handle.net/10397/24739
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/ol1028892
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