Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24571
Title: Surface functionalized gold nanoparticles for drug delivery
Authors: Cheng, J
Gu, YJ
Cheng, SH
Wong, WT 
Keywords: Biocompatibility
Doxorubicin
Drug delivery
Gold nanoparticles
Multidrug resistance
Issue Date: 2013
Source: Journal of biomedical nanotechnology, 2013, v. 9, no. 8, p. 1362-1369 How to cite?
Journal: Journal of Biomedical Nanotechnology 
Abstract: Gold nanoparticles have been widely explored as cancer therapeutics and diagnostic agents in recent years. With their unique subcellular size and good biocompatibility, gold nanoparticles are a promising drug delivery vehicle. In this study, folic acid-coated gold nanoparticles conjugated with fluorophore FITC through amine terminated poly(ethylene glycol) were prepared and confocal microscopy together with bright-field differential interference contrast imaging data showed that folic acid-coated gold nanoparticles accumulated mainly in cytoplasm of primary human fibroblasts, without causing any observable cytotoxicity upon exposure for 48 hours. Through the further development of a drug delivery system that conjugates doxorubicin onto the surface of gold nanoparticles with a poly(ethylene glycol) spacer via an SMCC linker, we demonstrated that multidrug resistance in cancer cells can be significantly overcome by a combination of highly efficient cellular entry and enhanced cytotoxicity of Au-SMCC-DOX nanoconjugates, as revealed both by confocal microscopy imaging and cytotoxicity assay. The prepared Au-SMCC-DOX nanoconjugates demonstrated enhanced drug accumulation and retention in multidrug resistant hepG2-R cancer cells when it was compared with free doxorubicin, with a cytoplasm accumulation profile. The results indicated that gold nanoparticles are a kind of promising drug delivery vehicle with good biocompatibility and suitable for further applications in drug delivery for improved chemotherapy, especially for overcoming multidrug resistance.
URI: http://hdl.handle.net/10397/24571
ISSN: 1550-7033
DOI: 10.1166/jbn.2013.1536
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