Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24534
Title: Pharmaceutical analysis by solid-substrate electrospray ionization mass spectrometry with wooden tips
Authors: Yang, Y
Deng, J
Yao, ZP 
Keywords: Active components
Chemical fingerprint
Degradation products
Pharmaceutical analysis
Wooden-tip electrospray ionization
Issue Date: 2014
Publisher: Springer
Source: Journal of the American society for mass spectrometry, 2014, v. 25, no. 1, p. 37-47 How to cite?
Journal: Journal of the American Society for Mass Spectrometry 
Abstract: Electrospray ionization (ESI) using wooden tips as solid substrates allows direct ionization of various samples and their simple and efficient analyses by mass spectrometry (MS). In this study, wooden-tip ESI-MS was used for pharmaceutical analysis. A wide variety of active components present in pharmaceuticals with forms of tablets, capsules, granules, dry suspensions, suspensions, drops, and oral liquids, etc.; were all successfully ionized directly for mass spectrometric analysis. Trace degradation products were also sensitively detected using wooden-tip ESI-MS. This strategy was extended to construct chemical fingerprints of herbal products containing complex and unknown components, and the fingerprints provided valuable information for their quality assessment and origin tracing. Our experimental data demonstrated that wooden-tip ESI-MS is a useful tool for rapid pharmaceutical analysis, with high sensitivity and wide applicability, showing promising perspectives for quality assessment and control, authentication, and origin tracing of pharmaceuticals.
URI: http://hdl.handle.net/10397/24534
ISSN: 1044-0305
DOI: 10.1007/s13361-013-0748-0
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