Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24490
Title: Catalytic asymmetric alkynylation and arylation of aldehydes by an H-8-binaphthyl-based amino alcohol ligand
Authors: Ruan, J
Lu, G
Xu, L
Li, YM
Chan, ASC
Keywords: Alkynylation
Amino alcohols
Arylation
Asymmetric catalysis
H-8-binaphthyl
Nucleophilic addition
Issue Date: 2008
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2008, v. 350, no. 1, p. 76-84 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: A novel chiral H-8-1,1'-binaphthyl-based amino alcohol ligand (1R(a),2S,3R)-2 has been synthesized and applied in the direct nucleophilic addition of organozincs (alkynylzinc and arylzinc prepared in situ) to aldehydes, yielding the corresponding optically active propargylic alcohols and diarylmethanols in high yields and good to excellent enantioselectivities. For the asymmetric arylation reaction, one catalyst (1R(a),2S,3R)-2 can afford both enantiomers of many pharmaceutically interesting diarylmethanols by a proper combination of various arylzinc reagents and aldehydes.
URI: http://hdl.handle.net/10397/24490
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.200700215
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