Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24458
Title: Muscle apoptotic response to denervation, disuse, and aging
Authors: Siu, PM 
Keywords: Cell death
Muscle apoptosis
Muscle atrophy
Protein degradation
Sarcopenia
Tunel
Issue Date: 2009
Publisher: Lippincott Williams & Wilkins
Source: Medicine and science in sports and exercise, 2009, v. 41, no. 10, p. 1876-1886 How to cite?
Journal: Medicine and science in sports and exercise 
Abstract: Apoptosis is a tightly regulated biological process that plays an important role in coordinating cellular proliferation and differentiation. The pathological consequences of aberrant regulation of apoptosis have been widely demonstrated in carcinogenesis, neurodegenerative diseases, autoimmune diseases, viral infections, and acquired immunodeficiency syndrome. The study of apoptosis has been initiated in skeletal muscle biology. Consistent data have indicated the activation of apoptotic events in muscle atrophic conditions including neuromuscular diseases, muscle disuse, and sarcopenia. Although these results seem to link apoptosis to muscle atrophy, the causative role of apoptosis in this process still needs to be established. Further perspective studies are desired to reveal the precise mechanism and the exact physiologic role of apoptosis in muscle adaptation. This article aims to stimulate research into apoptosis in skeletal muscle. It reviews the apoptotic response of skeletal muscle to the atrophic conditions, namely, denervation, disuse, and aging, and discusses the proposed potential physiological links of apoptosis with muscle loss.
URI: http://hdl.handle.net/10397/24458
ISSN: 0195-9131
EISSN: 1530-0315
DOI: 10.1249/MSS.0b013e3181a6470b
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

26
Last Week
0
Last month
0
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

21
Last Week
0
Last month
0
Citations as of Aug 20, 2017

Page view(s)

31
Last Week
1
Last month
Checked on Aug 21, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.