Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24393
Title: Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules
Authors: Cheng, SY
Yuen, CWM
Lam, PL
Gambari, R
Wong, RSM
Cheng, GYM
Lai, PBS
Tong, SW
Chan, KW
Lau, FY
Kok, SHL
Lam, KH
Chui, CH
Keywords: Celecoxib
Chitosan
Cyclooxygenase 2
Oral administration
Issue Date: 2010
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry letters, 2010, v. 20, no. 14, p. 4147-4151 How to cite?
Journal: Bioorganic & medicinal chemistry letters 
Abstract: The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography-mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.
URI: http://hdl.handle.net/10397/24393
ISSN: 0960-894X
EISSN: 1464-3405
DOI: 10.1016/j.bmcl.2010.05.054
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