Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24269
Title: Synthesis of 8-hydroxyquinoline derivatives as novel antitumor agents
Authors: Chan, SH
Chui, CH
Chan, SW
Kok, SHL
Chan, D
Tsoi, MYT
Leung, PHM 
Lam, AKY
Chan, ASC
Lam, KH
Tang, JCO 
Keywords: 8-hydroxy-2-quinolinecarbaldehyde
antitumor
hepatocellular carcinoma
quinoline derivatives
Issue Date: 2013
Publisher: Amer Chemical Soc
Source: ACS medicinal chemistry letters, 2013, v. 4, no. 2, p. 170-174 How to cite?
Journal: ACS Medicinal Chemistry Letters 
Abstract: This letter describes the preparation of quinoline derivatives and their cytotoxic potentials toward human carcinoma cell lines. Among the selected compounds, 8-hydroxy-2-quinolinecarbaldehyde (3) showed the best in vitro cytotoxicity against the human cancer cell lines, including MDA231, T-47D, Hs578t, SaoS2, K562, SKHep1 (with a MTS50 range of 12.5-25 μg/mL) and Hep3B (with a MTS50 range of 6.25±0.034 μg/mL). The in vivo antitumor activity of compound 3 on subcutenaous Hep3B hepatocellular carcinoma xenograft in athymic nude mice was then studied. The results showed that the dose of 10 mg/kg/day of compound 3 with intraperitoneal injection for 9 days totally abolished the growth of the xenograft tumor of Hep3B with no histological damage on vital organs as compared with the control. The experimental results suggested that compound 3 has a good potential as an antitumor agent.
URI: http://hdl.handle.net/10397/24269
ISSN: 1948-5875
DOI: 10.1021/ml300238z
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