Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24204
Title: Synthesis and cytotoxicity study of alkannin derivatives
Authors: Huang, ZS
Wu, HQ
Duan, ZF
Xie, BF
Liu, ZC
Feng, GK
Gu, LQ
Chan, ASC
Li, YM
Keywords: β,β-Dimethylacrylalkannin
Alkannin derivatives
Conjugated addition
Cytotoxicity
Reductive alkylation
Issue Date: 2004
Source: European journal of medicinal chemistry, 2004, v. 39, no. 9, p. 755-764 How to cite?
Journal: European Journal of Medicinal Chemistry 
Abstract: Alkannin derivatives (3-19) were prepared through the reaction of β,β-dimethylacrylalkannin (1), the most abundant isohexenylnaphthazarin isolated from the roots of Arnebia euchroma, with different types of nucleophiles such as amines and thiols in the absence or presence of a reducing agent. The cytotoxicities of 1-8, 10-14 and 19 against four human carcinoma cell line (GLC-82, CNE2, Bel-7402, K-562) were found to be markedly higher than that of the naturally occurring β,β- dimethylacrylalkannin (1) and acetylalkannin (2). This study also shed light on the understanding of the biological activities in terms of the chemical reactivity of alkannins.
URI: http://hdl.handle.net/10397/24204
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2004.05.004
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