Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/24033
Title: Chiral squaric prolinols : a new type of ligand for the asymmetric reduction of prochiral ketones by borane
Authors: Zhang, J
Zhou, HB
Lu, SM
Luo, MM
Xie, RG
Choi, MCK
Zhou, ZY
Chan, ASC
Yang, TK
Issue Date: 2001
Publisher: Pergamon-Elsevier Science Ltd
Source: Tetrahedron asymmetry, 2001, v. 12, no. 13, p. 1907-1912 How to cite?
Journal: Tetrahedron Asymmetry 
Abstract: A series of chiral bifunctional squaric prolinol ligands, having N, S substituents at C(3) of the squaric ring were synthesized and applied to the asymmetric borane reduction of prochiral ketones via an in situ formed chiral boron heterocycle, affording secondary alcohols with high yields and excellent enantiomeric excesses (up to 99%). The crystal structure of 5a was obtained and the mechanism of the catalytic asymmetric reduction is also discussed.
URI: http://hdl.handle.net/10397/24033
ISSN: 0957-4166
DOI: 10.1016/S0957-4166(01)00333-0
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