Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23908
Title: Formation of apatite on poly(α-hydroxy acid) in an accelerated biomimetic process
Authors: Chen, Y
Mak, AFT
Li, J
Wang, M
Shum, AWT
Issue Date: 2005
Source: Journal of biomedical materials research. Part B, Applied biomaterials, 2005, v. 73, no. 1, p. 68-76
Abstract: Bonelike apatite coating was formed on poly(L-lactic acid) films and poly(glycolic acid) scaffolds within 24 h through an accelerated biomimetic process. The ion concentrations in the simulated body fluid (SBF) were nearly 5 times of those in the human blood plasma. The apatite formed was characterized by using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The apatite formed in 5SBFs was similar in morphology and composition to that formed in the classical biomimetic process using SBF or 1.5SBF and similar to that of natural bone. This indicated that the biomimetic apatite-coating process could be accelerated by using concentrated simulated body fluid at 37°C. Besides saving time, the accelerated biomimetic process is particularly significant to biodegradable polymers. Some polymers that degrade too fast to be coated with apatite by a classical biomimetic process (e.g., PGA) could be coated with bonelike apatite in an accelerated biomimetic process.
Keywords: Accelerated biomimetic process
Bonelike apatite
Poly(glycolic acid)
Poly(L-lactic acid)
Simulated body fluid
Publisher: John Wiley & Sons
Journal: Journal of biomedical materials research. Part B, Applied biomaterials 
ISSN: 1552-4973
EISSN: 1552-4981
DOI: 10.1002/jbm.b.30178
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

54
Last Week
0
Last month
0
Citations as of Sep 5, 2020

WEB OF SCIENCETM
Citations

51
Last Week
1
Last month
0
Citations as of Sep 19, 2020

Page view(s)

125
Last Week
3
Last month
Citations as of Sep 23, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.