Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23658
Title: Protection against 1-methyl-4-phenylpyridinium ion (MPP +)- induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells
Authors: Hu, S
Han, R
Mak, S
Han, Y 
Keywords: Ginseng (Panax ginseng C.A. Meyer)
Mitochondrial dysfunction
MPP +
Parkinson's disease (PD)
Reactive oxygen species (ROS)
Water extract of ginseng (WEG)
Issue Date: 2011
Publisher: Elsevier
Source: Journal of ethnopharmacology, 2011, v. 135, no. 1, p. 34-42 How to cite?
Journal: Journal of ethnopharmacology 
Abstract: Ethnopharmacological relevance: The present study investigates the protective effects of water extract of ginseng (Panax ginseng C.A. Meyer) against 1-methyl-4-phenylpyridinium ion (MPP +)-induced cytotoxicity in SH-SY5Y human neuroblastoma cells and explores the underlying mechanisms. The approach may be used for screening therapeutic agents for degenerative disorders such as Parkinson's disease. Materials and methods: SH-SY5Y human neuroblastoma cells were used to analyze the protective effects of water extract of ginseng (WEG) against multiple parameters such as MPP +-induced viability, oxidative injury, expression of Bax, Bcl-2, cytochrome c and cleaved caspase-3. Results: WEG exerted inhibitory effect on cell death, overproduction of ROS, elevated Bax/Bcl-2 ratio, release of cytochrome c and activation of caspase-3 expression in MPP +-treated SH-SY5Y cells. Conclusions: WEG exhibited significant protective effects against MPP +-induced cytotoxicity in SH-SY5Y cells possibly through the suppression of ROS generation and the inhibition of mitochondria-dependent apoptotic pathway.
URI: http://hdl.handle.net/10397/23658
ISSN: 0378-8741
EISSN: 1872-7573
DOI: 10.1016/j.jep.2011.02.017
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