Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23635
Title: Unique substrate recognition mechanism of the botulinum neurotoxin D light chain
Authors: Guo, J
Chen, S 
Issue Date: 2013
Publisher: Amer Soc Biochemistry Molecular Biology Inc
Source: Journal of biological chemistry, 2013, v. 288, no. 39, p. 27881-27887 How to cite?
Journal: Journal of Biological Chemistry 
Abstract: Background: The mechanism of botulinum neurotoxin D light chain (LC/D) substrate recognition is not well defined. Results: A dual recognition strategy employed by LC/D was revealed, in which one site of VAMP-2 was recognized by two independent, functionally similar LC/D sites that were complementary to each other. Conclusion: LC/D utilizes a unique mechanism for substrate recognition. Significance: This study provides insights for LC/D engineering and antitoxin development.
URI: http://hdl.handle.net/10397/23635
ISSN: 0021-9258
DOI: 10.1074/jbc.M113.491134
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