Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/2334
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dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorLi, WY-
dc.creatorChan, SW-
dc.creatorGuo, D-
dc.creatorChung, MK-
dc.creatorLeung, TY-
dc.creatorYu, PH-
dc.date.accessioned2014-12-11T08:29:05Z-
dc.date.available2014-12-11T08:29:05Z-
dc.identifier.issn0378-8741-
dc.identifier.urihttp://hdl.handle.net/10397/2334-
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsJournal of Ethnopharmacology © 2009 Elsevier Ireland Ltd. The journal web site is located at http://www.sciencedirect.com.en_US
dc.subjectRheum officinale Baill.en_US
dc.subjectTraditional Chinese medicineen_US
dc.subjectAnticanceren_US
dc.subjectApoptosisen_US
dc.subjectMCF-7en_US
dc.subjectA549en_US
dc.titleWater extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell linesen_US
dc.typeJournal/Magazine Articleen_US
dc.description.otherinformationAuthor name used in this publication: De-Jian Guoen_US
dc.description.otherinformationAuthor name used in this publication: Peter Hoi-Fu Yuen_US
dc.identifier.spage251-
dc.identifier.epage256-
dc.identifier.volume124-
dc.identifier.issue2-
dc.identifier.doi10.1016/j.jep.2009.04.030-
dcterms.abstractEthnopharmacological relevance: Rheum officinale Baill. (Da Huang) is one of the herbs commonly used in traditional Chinese medicine formulae against cancer. The traditional decoction is similar to the water extract used in the present study.-
dcterms.abstractAim of the study: The water extract of Da Huang was investigated to see if it possesses anticancer effects through apoptotic pathways.-
dcterms.abstractMaterials and methods: Human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines were treated with different concentrations of Da Huang water extract at different time intervals. Growth inhibition was detected by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)- 2-(4-sulfophenyl)-2H-tetrazolium] and colony formation assays; apoptosis was detected by cell morphologic analysis, DNA fragmentation analysis and COMET assay.-
dcterms.abstractResults: Da Huang water extract was found to have significant growth inhibitory effects on both A549 and MCF-7 cell lines with IC[sub 50] values 620±12.7 and 515±10.1 µg/ml, respectively. Growth inhibitory effects were dose- and time-dependent. A significant decrease in cell number, DNA fragmentation and single DNA strand breakages were observed in the Da Huang water extract treated A549 and MCF-7 cells.-
dcterms.abstractConclusions: This suggests that the water extract of Da Huang exerts potential anticancer activity through growth inhibition and apoptosis on MCF-7 and A549 cells lines.-
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of Ethnopharmacology, 15 July 2009, v. 124, no. 2, p. 251-256-
dcterms.isPartOfJournal of ethnopharmacology-
dcterms.issued2009-07-15-
dc.identifier.isiWOS:000268286700013-
dc.identifier.scopus2-s2.0-67449158739-
dc.identifier.pmid19397973-
dc.identifier.eissn1872-7573-
dc.identifier.rosgroupidr46163-
dc.description.ros2009-2010 > Academic research: refereed > Publication in refereed journal-
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberOA_IR/PIRAen_US
dc.description.pubStatusPublisheden_US
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