Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/2330
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Zheng, YP | - |
dc.creator | Shi, J | - |
dc.creator | Qin, L | - |
dc.creator | Patil, SG | - |
dc.creator | Mow, VC | - |
dc.creator | Zhou, KY | - |
dc.date.accessioned | 2014-12-11T08:28:55Z | - |
dc.date.available | 2014-12-11T08:28:55Z | - |
dc.identifier.issn | 0301-5629 | - |
dc.identifier.uri | http://hdl.handle.net/10397/2330 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Ultrasound in Medicine and Biology © 2004 World Federation for Ultrasound in Medicine & Biology. The journal web site is located at http://www.sciencedirect.com. | en_US |
dc.subject | Ultrasound | en_US |
dc.subject | Articular cartilage | en_US |
dc.subject | Osteoarthritis | en_US |
dc.subject | Osmotic swelling | en_US |
dc.subject | Solute diffusion | en_US |
dc.title | Dynamic depth-dependent osmotic swelling and solute diffusion in articular cartilage monitored using real-time ultrasound | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.description.otherinformation | Author name used in this publication: Y. P. Zheng | en_US |
dc.description.otherinformation | Author name used in this publication: J. Shi | en_US |
dc.description.otherinformation | Author name used in this publication: S. G. Patil | en_US |
dc.identifier.spage | 841 | - |
dc.identifier.epage | 849 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 6 | - |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2004.02.009 | - |
dcterms.abstract | The objective of this study was to investigate the feasibility of ultrasonic monitoring for the transient depth-dependent osmotic swelling and solute diffusion in normal and degenerated articular cartilage (artC) tissues. Full-thickness artC specimens were collected from fresh bovine patellae. The artC specimens were continuously monitored using a focused beam of 50 MHz ultrasound (US) during sequential changes of the bathing solution from 0.15 mol/L to 2 mol/L saline, 0.15 mol/L saline, 1 mg/mL trypsin solution, 0.15 mol/L saline, 2 mol/L saline and back to 0.15 mol/L saline. The transient displacements of US echoes from the artC tissues at different depths were used to represent the tissue deformation and the NaCl diffusion. The trypsin solution was used selectively to digest the proteoglycans in artC. It was demonstrated that high-frequency US was feasible for monitoring the transient osmotic swelling, solute transport and progressive degeneration of artC in real-time. Preliminary results showed that the normal bovine patellar artC shrank during the first several minutes and then recovered to its original state in approximately 1 h when the solution was changed from 0.15 mol/L to 2 mol/L saline. Degenerated artC showed neither shrinkage nor recovery during the same process. In addition, a dehydrated-hydrated artC specimen showed much stronger shrinkage and it resumed the original state when the solution was changed from 2 mol/L back to 0.15 mol/L saline. The diffusion of NaCl and the digestion process of proteoglycans induced by trypsin were also successfully monitored in real-time. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Ultrasound in medicine and biology, June 2004, v. 30, no. 6, p. 841-849 | - |
dcterms.isPartOf | Ultrasound in medicine and biology | - |
dcterms.issued | 2004-06 | - |
dc.identifier.isi | WOS:000222410600015 | - |
dc.identifier.scopus | 2-s2.0-3042558651 | - |
dc.identifier.pmid | 15219963 | - |
dc.identifier.eissn | 1879-291X | - |
dc.identifier.rosgroupid | r16795 | - |
dc.description.ros | 2003-2004 > Academic research: refereed > Publication in refereed journal | - |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | OA_IR/PIRA | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Zheng et al UMB 2004 Depth-dependent osmotic swelling.pdf | Pre-published version | 1.13 MB | Adobe PDF | View/Open |
Page views
131
Last Week
1
1
Last month
Citations as of Apr 21, 2024
Downloads
185
Citations as of Apr 21, 2024
SCOPUSTM
Citations
29
Last Week
0
0
Last month
0
0
Citations as of Apr 5, 2024
WEB OF SCIENCETM
Citations
25
Last Week
0
0
Last month
0
0
Citations as of Apr 25, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.