Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23281
Title: Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia
Authors: Miyake, M
Yamashiro, K
Tabara, Y
Suda, K
Morooka, S
Nakanishi, H
Khor, CC
Chen, P
Qiao, F
Nakata, I
Akagi Kurashige, Y
Gotoh, N
Tsujikawa, A
Meguro, A
Kusuhara, S
Polasek, O
Hayward, C
Wright, AF
Campbell, H
Richardson, AJ
Schache, M
Takeuchi, M
MacKey, DA
Hewitt, AW
Cuellar, G
Shi, Y
Huang, L
Yang, Z
Leung, KH
Kao, PYP
Yap, MKH 
Yip, SP 
Moriyama, M
Ohno Matsui, K
Mizuki, N
MacGregor, S
Vitart, V
Aung, T
Saw, SM
Tai, ES
Wong, TY
Cheng, CY
Baird, PN
Yamada, R
Matsuda, F
Yoshimura, N
Issue Date: 2015
Publisher: Nature Publishing Group
Source: Nature communications, 2015, v. 6, 6689, p. V- How to cite?
Journal: Nature Communications 
Abstract: Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta =3.9 ¡Ñ 10-13) and corneal curvature (Pmeta =2.9 ¡Ñ 10-40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta =1.13, Pmeta =0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.
URI: http://hdl.handle.net/10397/23281
EISSN: 2041-1723
DOI: 10.1038/ncomms7689
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