Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23231
Title: Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors
Authors: Shen, Q
Peng, Q
Shao, J
Liu, X
Huang, Z
Pu, X
Ma, L
Li, YM
Chan, ASC
Gu, L
Keywords: Cholinesterase inhibitor
Functionalized coumarins
Synthesis
Issue Date: 2005
Publisher: Elsevier Masson
Source: European journal of medicinal chemistry, 2005, v. 40, no. 12, p. 1307-1315 How to cite?
Journal: European journal of medicinal chemistry 
Abstract: Three series of functionalized coumarin compounds were designed and prepared as cholinesterase (AChE and BuChE) inhibitors. The biological profile against AChE and BuChE of the prepared compounds was determined. Compound 7b exhibited a mixed-type of AChE inhibitor with IC50 value for the AChE inhibition of 0.19 ± 0.01 μM and a high selectivity for AChE/BuChE, and compound 6b acted as non-competitive AChE inhibitor with IC50 value of 0.43 ± 0.02 μM. Structure-activity relationships (SARs) of prepared compounds were discussed.
URI: http://hdl.handle.net/10397/23231
ISSN: 0223-5234
EISSN: 1768-3254
DOI: 10.1016/j.ejmech.2005.07.014
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