Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23226
Title: Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus : a double blind, placebo controlled pilot study
Authors: Tam, LS
Li, EK
Leung, VY
Griffith, JF
Benzie, IFF 
Lim, PL
Whitney, B
Lee, VW
Lee, KK
Thomas, GN
Tomlinson, B.
Keywords: Antioxidants
Controlled trial
Endothelial function
Oxidative stress
Systemic lupus erythematosus
Issue Date: 2005
Source: Journal of rheumatology, 2005, v. 32, no. 2, p. 275-282 How to cite?
Journal: Journal of Rheumatology 
Abstract: Objective. Patients with systemic lupus erythematosus (SLE) experience excess morbidity and mortality due to coronary artery disease (CAD) that cannot be fully explained by the classical CAD risk factors. Among emerging CAD risk factors, oxidative stress is currently being emphasized. We evaluated the effects of longterm antioxidant vitamins on markers of oxidative stress and antioxidant defense and endothelial function in 39 patients with SLE. Methods. Patients were randomized to receive either placebo or vitamins (500 mg vitamin C and 800 IU vitamin E daily) for 12 weeks. Markers of oxidative stress included malondialdehyde (MDA) and allantoin. Antioxidants measured included erythrocyte superoxide dismutase and glutathione peroxidase, plasma total antioxidant power (as FRAP value), and ascorbic acid and vitamin E concentrations. Endothelial function was assessed by flow-mediated dilatation (FMD) of the brachial artery and plasma concentration of von Willebrand factor (vWF) and plasminogen activator inhibitor type 1 (PAI-1). Primary outcome of the study included the change in lipid peroxidation as revealed by MDA levels. Secondary outcomes included changes in allantoin and antioxidant levels and change in endothelial function. Results. After treatment, plasma ascorbic acid and α-tocopherol concentrations were significantly (p < 0.05) increased only in the vitamin-treated group, associated with a significant decrease (p < 0.05) in plasma MDA. Other oxidative stress markers and antioxidant levels remained unchanged in both groups. FMD and vWF and PAI-1 levels remained unchanged in both groups. Conclusion. Combined administration of vitamins C and E was associated with decreased lipid peroxidation, but did not affect endothelial function in patients with SLE after 3 months of therapy.
URI: http://hdl.handle.net/10397/23226
ISSN: 0315-162X
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

59
Last Week
0
Last month
0
Citations as of Oct 8, 2017

WEB OF SCIENCETM
Citations

41
Last Week
0
Last month
1
Citations as of Oct 15, 2017

Page view(s)

48
Last Week
0
Last month
Checked on Oct 15, 2017

Google ScholarTM

Check



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.