Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23162
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technology-
dc.creatorLiu, J-
dc.creatorLeung, CH-
dc.creatorChow, ALF-
dc.creatorSun, RWY-
dc.creatorYan, SC-
dc.creatorChe, CM-
dc.date.accessioned2015-06-23T09:11:33Z-
dc.date.available2015-06-23T09:11:33Z-
dc.identifier.issn1359-7345-
dc.identifier.urihttp://hdl.handle.net/10397/23162-
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.titleCyclometalated platinum(II) complexes as topoisomerase II alpha poisonsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage719-
dc.identifier.epage721-
dc.identifier.volume47-
dc.identifier.issue2-
dc.identifier.doi10.1039/c0cc03641b-
dcterms.abstractA platinum(II)-based major groove binder [Pt(II)(C boolean AND N) (C NR)(2)](+) (HC boolean AND N = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase II alpha poison. It stabilizes the covalent TopoII alpha-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoII alpha poison Vp-16.-
dcterms.bibliographicCitationChemical communications, 2011, v. 47, no. 2, p. 719-721-
dcterms.isPartOfChemical communications-
dcterms.issued2011-
dc.identifier.isiWOS:000285300400028-
dc.identifier.eissn1364-548X-
dc.identifier.rosgroupidr53840-
dc.description.ros2010-2011 > Academic research: refereed > Publication in refereed journal-
Appears in Collections:Journal/Magazine Article
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