Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/23162
Title: Cyclometalated platinum(II) complexes as topoisomerase II alpha poisons
Authors: Liu, J
Leung, CH
Chow, ALF
Sun, RWY
Yan, SC
Che, CM
Issue Date: 2011
Publisher: Royal Society of Chemistry
Source: Chemical communications, 2011, v. 47, no. 2, p. 719-721 How to cite?
Journal: Chemical communications 
Abstract: A platinum(II)-based major groove binder [Pt(II)(C boolean AND N) (C NR)(2)](+) (HC boolean AND N = 2-phenylpyridine (phpy), R = 2-naphthyl) was identified as a potent human topoisomerase II alpha poison. It stabilizes the covalent TopoII alpha-DNA cleavage complex and induces cancer cell death with potency significantly higher than the widely clinically used TopoII alpha poison Vp-16.
URI: http://hdl.handle.net/10397/23162
ISSN: 1359-7345
EISSN: 1364-548X
DOI: 10.1039/c0cc03641b
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