Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22970
Title: Rhodium-catalyzed asymmetric hydrogenation with aminophosphine ligands derived from 1,1 '-binaphthyl-2,2 '-diamine
Authors: Guo, RW
Li, XS
Wu, J
Kwok, WH
Chen, J
Choi, MCK
Chan, ASC
Issue Date: 2002
Source: Tetrahedron letters, 2002, v. 43, no. 38, p. 6803-6806
Abstract: Chiral ligands 2,2'-bis(dicyclohexylphosphinoamino)-1,1'-binaphthyI and 2,2'-bis[bis(3,5-dimethylphenyl)phosphinoamino]- 1,1'-binaphthyl were synthesized by reacting 1,1'-binaphthyl-2,2'-diamine with dicyclohexylchlorophosphine and bis(3,5-dimethylphenyl)chlorophosphine, respectively. Application of these ligands to the Rh-catalyzed asymmetric hydrogenation of a variety of amidoacrylic acids and esters provided chiral amino acid derivatives with excellent enantioselectivities (up to 99% e.e. and quantitative yields).
Keywords: Aminophosphine ligand
Asymmetric hydrogenation
Rhodium
Amino acid derivatives
Publisher: Pergamon Press
Journal: Tetrahedron letters 
ISSN: 0040-4039
EISSN: 1873-3581
DOI: 10.1016/S0040-4039(02)01510-1
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