Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22894
Title: A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation
Authors: Chan, SLF 
Lu, L
Lam, TL
Yan, SC
Leung, CH
Ma, DL
Keywords: 2-acetylbenzo[b]thiophen-3-olate
Alzheimer's disease
Beta-amyloid
Ruthenium(II)
Tris(2-pyridylmethyl)amine
Issue Date: 2015
Publisher: Bentham Science Publishers B.V.
Source: Current alzheimer research, 2015, v. 12, no. 5, p. 434-438 How to cite?
Journal: Current Alzheimer Research 
Abstract: We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
URI: http://hdl.handle.net/10397/22894
ISSN: 1567-2050
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