Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22746
Title: High myopia-partial reduction ortho-k : A 2-year randomized study
Authors: Charm, J
Cho, P 
Keywords: High myope
Myopia control
Myopic progression
Orthokeratology
Partial correction
Issue Date: 2013
Publisher: Lippincott Williams & Wilkins
Source: Optometry and vision science, 2013, v. 90, no. 6, p. 530-539 How to cite?
Journal: Optometry and vision science 
Abstract: PURPOSE: To investigate if the combination of partial reduction (PR) orthokeratology (ortho-k) and spectacles for residual refractive errors in the daytime was effective to slow myopic progression in high myopic children. METHODS: High myopic children (aged 8 to 11 years) with spherical equivalent refraction at least -5.75 diopters (D) and myopia -5.00 D or more myopic were recruited and randomly assigned into PR ortho-k and control groups. Subjects in the PR ortho-k group were fitted with custom made four-zone ortho-k lenses with target reduction of 4.00 D for both eyes, and the residual refractive errors were corrected with single-vision spectacles for clear vision in the daytime. Control subjects were fully corrected with single-vision spectacles. Axial length of each eye of all subjects was measured with the IOLMaster at 6-month intervals by a masked examiner. This study was registered at www.clinicaltrial.gov with the identifier NCT00977236. RESULTS: Fifty-two subjects were recruited and randomized to the PR ortho-k and control groups. Twelve PR ortho-k and 16 control subjects completed the study. Compared with the residual refractive errors at the 1-month visit (after stabilization of ortho-k treatment), the median increase in noncycloplegic residual myopia at the 24-month visit was 0.13 D. In the control group, the median increase in myopia was 1.00 D at the end of the study. The mean ± SD increases in axial length were 0.19 ± 0.21 mm in the PR ortho-k group and 0.51 ± 0.32 mm in the control group (95% confidence interval, -0.55 to -0.12; unpaired t test, p = 0.005). CONCLUSIONS: This single-masked randomized study showed that PR ortho-k effectively slowed myopic progression in high myopes. Axial length elongation was 63% slower in PR ortho-k-treated children compared with children wearing spectacles.
URI: http://hdl.handle.net/10397/22746
ISSN: 1040-5488
EISSN: 1538-9235
DOI: 10.1097/OPX.0b013e318293657d
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