Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22682
Title: Photodynamic effects on nasopharyngeal carcinoma (NPC) cells with 5-aminolevulinic acid or its hexyl ester
Authors: Wu, RWK
Chu, ESM
Yow, CMN
Chen, JY
Keywords: 5-Aminolevulinic acid hexyl ester
Metastasis
Nasopharyngeal carcinoma
Photodynamic therapy
Issue Date: 2006
Source: Cancer letters, 2006, v. 242, no. 1, p. 112-119 How to cite?
Journal: Cancer Letters 
Abstract: Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Hong Kong and southern China. To explore a new modality of NPC treatment, 5-aminolevulinic acid (ALA) or its hexyl ester (ALA-H) mediated photodynamic therapy (PDT) was studied in vitro. The results show that NPC cells are sensitive to both ALA and ALA-H mediated PDT. However, ALA-H PDT is much more effective at cell inactivation than ALA-PDT, due to a higher efficiency of ALA-H on producing endogenous protoporphyrin (PpIX) in cells. Both apoptosis and necrosis are involved in cell death, but apoptosis plays a major role under the short time incubation of drugs. ALA and ALA-H mediated PDT not only destroy the cells directly, but also inhibit the expression of matrix metalloproteinase-2 (MMP2) in cells, a maker for tumor metastasis. The ALA-H shows promising PDT results on NPC in vitro; therefore it is worth investigating further in vivo for NPC treatment.
URI: http://hdl.handle.net/10397/22682
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2005.10.048
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

25
Last Week
0
Last month
0
Citations as of Aug 20, 2017

WEB OF SCIENCETM
Citations

23
Last Week
1
Last month
0
Citations as of Aug 4, 2017

Page view(s)

42
Last Week
3
Last month
Checked on Aug 20, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.