Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22662
Title: A flavonol glycoside, isolated from roots of panax notoginseng, reduces amyloid-beta-induced neurotoxicity in cultured neurons : signaling transduction and drug development for alzheimer's disease
Authors: Choi, RCY
Zhu, JTT
Leung, KW
Chu, GKY
Xie, HQ
Chen, VP
Zheng, KYZ
Lau, DTW
Dong, TTX
Chow, PCY
Han, YF 
Wang, ZT
Tsim, KWK
Keywords: Alzheimer's disease
Chinese medicine
Flavonol glycoside
Neuroprotection
Panax notoginseng
Issue Date: 2010
Publisher: IOS Press
Source: Journal of alzheimer's disease, 2010, v. 19, no. 3, p. 795-811 How to cite?
Journal: Journal of alzheimer's disease 
Abstract: A Radix Notoginseng flavonol glycoside (RNFG), quercetin 3-O-beta-D-xylopyranosyl-beta-D-galactopyranoside, was isolated from roots of Panax notoginseng. Among different biological properties tested, RNFG possessed a strong activity in preventing amyloid-beta (A beta)-induced cell death. In an in vitro assay, RNFG inhibited the aggregation of A beta in a dose-dependent manner. Moreover, application of RNFG in cultured cortical neurons, or PC12 cells, reduced the A beta-induced cell death in time-and dose-dependent manners, with the suppression of A beta-induced DNA fragmentation and caspase-3 activation. In cultured neurons, the pre-treatment of RNFG abolished the increase of Ca(2+) mobilization triggered by A beta. The neuroprotective properties of RNFG required a specific sugar attachment within the main chemical backbone because the flavonol backbone by itself did not show any protective effect. In memory impairment experiments using the passive avoidance task, the administration of RNFG reduced brain damage in scopolamine-treated rats. These results therefore reveal a novel function of Radix Notoginseng and its flavonol glycoside that could be very useful in developing food supplements for the prevention, or potential treatment, of Alzheimer's disease.
URI: http://hdl.handle.net/10397/22662
ISSN: 1387-2877
EISSN: 1875-8908
DOI: 10.3233/JAD-2010-1293
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