Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22579
Title: Tanshinone production and isoprenoid pathways in Salvia miltiorrhiza hairy roots induced by Ag + and yeast elicitor
Authors: Ge, X
Wu, J 
Keywords: Elicitors
Hairy root culture
Isoprenoid pathways
Salvia miltiorrhiza
Tanshinones
Issue Date: 2005
Source: Plant science, 2005, v. 168, no. 2, p. 487-491 How to cite?
Journal: Plant Science 
Abstract: This work examined the accumulation of diterpenoid tanshinones and related secondary metabolism pathways in hairy root cultures of Salvia miltiorrhiza Bunge (Lamiacae) induced by a biotic elicitor, the carbohydrate fraction of yeast extract (YE, 100 μg mL -1), and an abiotic elicitor, Ag + (30 μM). The activity of 3-hydroxy-3-methylglutaryl CoA redutase (HMGR) was only stimulated by Ag +, and 1-deoxy-d-xylulose 5-phosphate synthase (DXS) was stimulated by both, but more strongly by YE. While the non-MVA pathway inhibitor fosmidomycin inhibited the tanshinone accumulation induced by both elicitors, the MVA-pathway inhibitor mevinolin only suppressed the Ag-induced tanshinone accumulation. The results suggest that the tanshinone accumulation induced by the two elicitors was mainly synthesized via the non-MVA pathway (DXS activity), but could depend on crosstalk between the MVA and non-MVA pathways. Furthermore, the pretreatment of hairy roots with Ag + for 24-48 h potentiated the YE-induced tanshinone production and DXS activity.
URI: http://hdl.handle.net/10397/22579
ISSN: 0168-9452
DOI: 10.1016/j.plantsci.2004.09.012
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