Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22545
Title: Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors
Authors: Wan, SB
Landis-Piwowar, KR
Kuhn, DJ
Chen, D
Dou, QP
Chan, TH
Issue Date: 2005
Source: Bioorganic and medicinal chemistry, 2005, v. 13, no. 6, p. 2177-2185
Abstract: The structure-activity relationship of a number of synthetic green tea polyphenol analogs involving modifications of A ring and B ring of epi-gallocatechin gallate (EGCG) as proteasome inhibitors has been examined. It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency.
Publisher: Pergamon-Elsevier Science Ltd
Journal: Bioorganic and Medicinal Chemistry 
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2004.12.056
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