Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22463
Title: Embryonic stem cells biosensor and its application in drug analysis and toxin detection
Authors: Liu, Q
Cai, H
Xiao, L
Li, R
Yang, M 
Wang, P
Keywords: Biosensor
Cardiomyocyte
Drug analysis
Embryonic stem cells
Light-addressable Potentiometrie sensor (LAPS)
Toxin detection
Issue Date: 2007
Publisher: Institute of Electrical and Electronics Engineers
Source: IEEE sensors journal, 2007, v. 7, no. 12, p. 1625-1630 How to cite?
Journal: IEEE sensors journal 
Abstract: To investigate the use of stem cells as biosensor elements, a novel cell-based light-addressable Potentiometric sensor (LAPS) was developed for monitoring cellular beating. Mouse embryonic stem cells were induced to differentiate into cardiomyocytes in vitro. Extracellular field potentials of spontaneously beating cardiomyocytes induced from stem cells were recorded by LAPS in the potential and frequency ranges of 25-45 ?gV and 0.5-3 Hz, respectively. Due to its capability of monitoring important physiological parameters such as potential and frequency in vitro, the sensor can be used in drug analysis and toxin detection in a long-term and noninvasive way. The pharmacological and toxicological researches make it possible to use stem cells-based biosensor for biomedical assays.
URI: http://hdl.handle.net/10397/22463
ISSN: 1530-437X
DOI: 10.1109/JSEN.2007.908439
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