Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22374
Title: The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy
Authors: Wang, G
Wang, J
Zhao, H
Wang, J
To, SST 
Keywords: Glioblastoma
Glucose metabolism
Let-7a miRNA
Myc
Pathways
Tumor growth
Issue Date: 2015
Publisher: Academic Press
Source: Archives of biochemistry and biophysics, 2015, v. 580, p. 84-92 How to cite?
Journal: Archives of biochemistry and biophysics 
Abstract: Glioblastoma multiforme (GBM) is thought to result from an imbalance between glucose metabolism and tumor growth. The Myc oncogene and lethal-7a microRNA (let-7a miRNA) have been suggested to cooperatively regulate multiple downstream targets leading to changes in chromosome stability, gene mutations, and/or modulation of tumor growth. Here, we review the roles of Myc and let-7a in glucose metabolism and tumor growth and addresses their future potential as prognostic markers and therapeutic tools in GBM. We focus on the functions of Myc and let-7a in glucose uptake, tumor survival, proliferation, and mobility of glioma cells. In addition, we discuss how regulation of different pathways by Myc or let-7a may be useful for future GBM therapies. A large body of evidence suggests that targeting Myc and let-7a may provide a selective mechanism for the deregulation of glucose metabolic pathways in glioma cells. Indeed, Myc and let-7a are aberrantly expressed in GBM and have been linked to the regulation of cell growth and glucose metabolism in GBM. This article is part of a Special Issue entitled "Targeting alternative glucose metabolism and regulate pathways in GBM cells for future glioblastoma therapies".
URI: http://hdl.handle.net/10397/22374
ISSN: 0003-9861
EISSN: 1096-0384
DOI: 10.1016/j.abb.2015.07.005
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