Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22308
Title: Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions
Authors: Zhou, X
Chan, SW
Tseng, HL
Deng, Y
Hoi, PM
Choi, PS
Or, PMY
Yang, JM
Lam, FFY
Lee, SMY
Leung, GPH
Kong, SK
Ho, HP
Kwan, YW
Yeung, JHK
Keywords: Antioxidant
Microwave water extraction
Phenolic acid
Salvia miltiorrhiza
Tanshinones
Vascular relaxation
Issue Date: 2012
Publisher: Elsevier Gmbh, Urban & Fischer Verlag
Source: Phytomedicine, 2012, v. 19, no. 14, p. 1263-1269 How to cite?
Journal: Phytomedicine 
Abstract: Some of the major components of Danshen (Salvia miltiorrhiza), a widely used Chinese herbal medicine rich in phenolic acids, are thermosensitive and may degrade to other phenolic acids during extractions with heating. The chemical profiles of Danshen water-extract may vary with different heat water extraction at different temperatures, affecting the composition and bioactivity of the extracts. In this study, six water-extracts of Danshen obtained from heat reflux water extraction and microwave-assisted extraction with water (MAE-W) at different temperatures were tested for their composition and pharmacological effects. Among these extracts, the third-round MAE-W (100 ?XC) extract had the highest phenolic acids and tanshinones contents, with the strongest antioxidant activity in 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) assay and ferric reducing/antioxidant potential (FRAP) assay. This extract also showed the strongest inhibitory effects on 2,2??-azobis-2-amidinopropane (AAPH)-induced hemolysis in human red blood cells, hydrogen peroxide-induced apoptosis in rat heart H9c2 cells and the highest relaxation effects on rat basilar artery. The antioxidant effects of Danshen water-extracts linearly correlated to their relaxation effects (r = 0.895-0.977). Through multiple linear regression analysis, danshensu was found to be the most significant marker in the antioxidant
URI: http://hdl.handle.net/10397/22308
ISSN: 0944-7113
DOI: 10.1016/j.phymed.2012.08.011
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