Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22186
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dc.contributorSchool of Optometry-
dc.creatorChu, PHW-
dc.creatorNg, YF-
dc.creatorTo, CH-
dc.creatorSo, KF-
dc.creatorBrown, B-
dc.creatorChan, HHL-
dc.date.accessioned2015-07-14T01:28:23Z-
dc.date.available2015-07-14T01:28:23Z-
dc.identifier.issn0721-832X-
dc.identifier.urihttp://hdl.handle.net/10397/22186-
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rights© Springer-Verlag 2011en_US
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in Graefe's Archive for Clinical and Experimental Ophthalmology. The final authenticated version is available online at: https://doi.org/10.1007/s00417-011-1790-x.en_US
dc.subjectAdaptive indexen_US
dc.subjectAsymmetric glaucomaen_US
dc.subjectGlobal flashen_US
dc.subjectMultifocal electroretinogramen_US
dc.subjectOcular hypertensionen_US
dc.titleLuminance-modulated adaptation in the global flash mfERG : a preliminary study of early retinal functional changes in high-risk glaucoma patientsen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage261-
dc.identifier.epage270-
dc.identifier.volume250-
dc.identifier.issue2-
dc.identifier.doi10.1007/s00417-011-1790-x-
dcterms.abstractPurpose To investigate the association of the luminancemodulation global flash multifocal electroretinogram (mfERG) and other clinical assessments of vision in subsets of subjects at high risk of developing glaucomatous damage. Methods Eighteen subjects (28 eyes) with asymmetric glaucoma and ocular hypertension were measured in this longitudinal study of visual field, OCT, and multifocal electroretinogram (mfERG). Five ophthalmic examinations were scheduled, once every 12 months over a 4-year period. The mfERG was assessed using a luminancemodulated global flash stimulation paradigm. The adaptive index which we have reported previously was calculated. Results There was a significant thinning of the peripapillary retinal nerve fiber layer over the course of the study for eyes with ocular hypertension, or for fellow eyes with asymmetric glaucoma which initially had an abnormal adaptive index; such eyes showed a thinning rate of -3.59 and -3.69 μm/year, respectively. However, no significant thinning was found for eyes which initially had a normal adaptive index. Two subjects were shown to have glaucomatous damage, confirmed by abnormal thinning of the retinal nerve fiber layer and visual field loss respectively at the last visit. However, these patients had shown an abnormal adaptive index in the mfERG measurement at the first visit. Conclusions The adaptive index calculated from the measurement of luminance-modulated global flash mfERG is useful for predicting progression of signs related to glaucoma, especially in high-risk groups. The abnormal adaptive index reflects the change in fast-adaptive mechanisms in the retina and indicates the risk of developing glaucoma.-
dcterms.accessRightsopen access-
dcterms.bibliographicCitationGraefe's archive for clinical and experimental ophthalmology, Feb. 2012, v. 250, no. 2, p. 261-270-
dcterms.isPartOfGraefe's archive for clinical and experimental ophthalmology-
dcterms.issued2012-02-
dc.identifier.isiWOS:000300290600013-
dc.identifier.scopus2-s2.0-84857371949-
dc.identifier.pmid21881844-
dc.identifier.eissn1435-702X-
dc.identifier.rosgroupidr59171-
dc.description.ros2011-2012 > Academic research: refereed > Publication in refereed journal-
dc.description.oaAccepted Manuscript-
dc.identifier.FolderNumbera0764-n10, a0780-n05-
dc.identifier.SubFormID1614, 1629-
dc.description.fundingSourceRGC-
dc.description.fundingSourceOthers-
dc.description.fundingTextRGC: PolyU 5384/04M-
dc.description.fundingTextOthers: G-YX3C, J-BB76-
dc.description.pubStatusPublished-
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