Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/22061
Title: Synthesis of a Class of Chiral-Bridged Phosphoramidite Ligands and Their Applications in the First Iridium-Catalyzed Asymmetric Addition of Arylboronic Acids to Isatins
Authors: Zhuang, Y
He, Y
Zhou, Z
Xia, W
Cheng, C
Wang, M
Chen, B
Zhou, Z
Pang, J
Qiu, L
Issue Date: 2015
Publisher: American Chemical Society
Source: Journal of organic chemistry, 2015, v. 80, no. 14, p. 6968-6975 How to cite?
Journal: Journal of organic chemistry 
Abstract: A series of novel chiral phosphoramidite ligands based on chiral-bridged biphenyl backbones have been prepared conveniently and characterized. The ligands complexed with [IrCodCl]2 provided the first iridium catalyst system for the asymmetric addition of arylboronic acids to N-protected isatins with high efficiency. When performed in THF/H2O at 80°C with 2 equiv of the arylboronic acids, the transformations acquired good to excellent results (up to 98% yield and 95% ee).
URI: http://hdl.handle.net/10397/22061
ISSN: 0022-3263
EISSN: 1520-6904
DOI: 10.1021/acs.joc.5b00595
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