Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21946
Title: Neurogenic hypothesis and psychiatric disorders
Authors: Lau, BWM
Lee, JCD
So, KF
Keywords: Amygdala
Anxiety disorder
Hippocampus
Major depression
Neurogenesis
Psychiatric disorders
Schizophrenia
Subventricular zone
Issue Date: 2013
Publisher: Chinese Academy of Sciences
Source: Chinese science bulletin (科學通報. 英文版), 2013, v. 58, no. 26, p. 3188-3198 How to cite?
Journal: Chinese science bulletin (科學通報. 英文版) 
Abstract: Psychiatric illness, such as affective disorders, anxiety disorders and schizophrenia, exerts exceptional personal burden on affected individuals. Although not physically noticeable, these disorders cost enormously on ones' family and society. Currently pharmaceutical and psychological treatments are generally accepted as effective for psychiatric disorders, while the exact mechanisms underlying the treatment efficacy, etiology and neurobiology of the disorders remain elusive. In the past decade, "neurogenic hypothesis" emerged as an attempt to explain the nature of psychiatric illness. The origination of the hypothesis is based on several pre-clinical and clinical observations. First, stress, which is a common risk factor of the disorders, was found to suppress neurogenesis; second, treatment for the illnesses like antidepressants and antipsychotics were shown to improve neurogenesis and behavioral deficits simultaneously; and third, the therapeutic effect of antidepressants was abolished in animal models when neurogenesis was blocked. Increasing efforts were invested to determine whether neurogenesis is a key to the understanding and treatment of psychiatric disorders, although contrasting results are also found and thus the importance of neurogenesis remains a matter of debate. The present chapter will discuss the recent findings about the involvement of neurogenesis in major depression, anxiety disorders and schizophrenia, and whether neurogenesis would be a potential target for development of the treatment in the future.
URI: http://hdl.handle.net/10397/21946
ISSN: 1001-6538
EISSN: 1861-9541
DOI: 10.1007/s11434-013-5886-z
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

1
Last Week
0
Last month
0
Citations as of Aug 17, 2017

Page view(s)

42
Last Week
4
Last month
Checked on Aug 21, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.