Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21935
Title: Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice
Authors: Guo, P
Cui, R
Chang, YZ
Wu, WS
Qian, ZM
Yoshida, K
Qiao, YT
Takeda, S
Duan, XL
Keywords: Hepcidin
Iron
Liver iron store
Serum iron
Transferrin saturation
Issue Date: 2009
Publisher: Elsevier Science Inc
Source: Peptides, 2009, v. 30, no. 2, p. 262-266 How to cite?
Journal: Peptides 
Abstract: Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver. Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content. In the present study, we explore the expression of murine hepcidin mRNA and further analyze the relationship between liver hepcidin mRNA expression, liver iron stores, and serum iron level utilizing ceruloplasmin gene knockout mice. We find that hepcidin expression correlates significantly with serum transferrin saturation, whereas there is a negative correlation of hepcidin expression with liver tissue iron level.
URI: http://hdl.handle.net/10397/21935
DOI: 10.1016/j.peptides.2008.09.017
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