Studies on the rhodium- and ruthenium-catalyzed asymmetric hydrogenation of alpha-dehydroamino acids using a family of chiral dipyridylphosphine ligand (P-Phos)

Abstract

The applications of the chiral dipyridylphosphine ligand P-Phos and its derivatives Tol-P-Phos and Xyl-P-Phos in Ru- and Rh-catalyzed hydrogenations of the methyl esters of a variety of (Z)-2-acetamido-3-arylacrylic acids have been studied systematically. The results show that the electronic and steric properties of these ligands have significant influences on the enantioselectivity of the reduction. Rh and Ru complexes of the same dipyridylphosphine ligand family exhibit different trends in enantioselectivity toward the same substrate.