Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21686
Title: ABO blood group in Kuwaitis : detailed allele frequency distribution and identification of novel alleles
Authors: Yip, SP 
Choi, PS
Lee, SY
Leung, KH
El-Zawahri, MM
Luqmani, YA
Issue Date: 2006
Publisher: Blackwell Publishing
Source: Transfusion, 2006, v. 46, no. 5, p. 773-779 How to cite?
Journal: Transfusion 
Abstract: BACKGROUND: The ABO blood group is clinically the most important blood group system and can now be genotyped easily by DNA-based methods without family studies. STUDY DESIGN AND METHODS: Samples (n = 166) from a Kuwaiti population were phenotyped by standard serologic techniques for the ABO blood group and genotyped for the ABO locus by an established multiplex polymerase chain reaction protocol followed by single-strand conformation polymorphism (SSCP) analysis. Nonstandard SSCP patterns were investigated by DNA sequencing of exons 6 and 7 and, if necessary intron 6. RESULTS: Standard SSCP patterns identified six classical alleles in this population: A101 (0.1115), A102 (0.0181), A201 (0.0301), B101 (0.1627), O101 (0.3103), and O201 (0.2500). One A, 1 B, and 8 O variant alleles were identified (total frequency, 0.1175). All variant alleles were each present in one or two chromosomes (≤0.0060) in our samples except O109 (0.0813). Three of these 10 variant alleles were novel alleles defined by newly identified single-nucleotide polymorphisms in exon 7 (527G>A, 687C>T, and 1116G>A). One new base substitution result in amino acid change. CONCLUSIONS: This is the first study reporting the detailed distribution of ABO alleles and genotypes in Kuwaitis. Sixteen alleles were identified, including 3 novel alleles.
URI: http://hdl.handle.net/10397/21686
ISSN: 0041-1132
DOI: 10.1111/j.1537-2995.2006.00796.x
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