Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21672
Title: Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment
Authors: Zhao, J
Chen, Z
Chen, S 
Deng, Y
Liu, Y
Tian, W
Huang, X
Wu, C
Sun, Y
Sun, Y
Zeng, Z
Liu, JH
Issue Date: 2010
Publisher: American Society for Microbiology
Source: Antimicrobial agents and chemotherapy, 2010, v. 54, no. 10, p. 4219-4224 How to cite?
Journal: Antimicrobial agents and chemotherapy 
Abstract: OqxAB has recently been identified as one of the mechanisms of plasmid-mediated quinolone resistance (PMQR). Compared to what is observed for other PMQR determinants, there is a paucity of data with regard to the prevalence and epidemiology of OqxAB and its contribution to resistance to different antimicrobials. In this study, the prevalence and dissemination of oqxAB and other PMQR genes in Escherichia coli isolates from animals, farmworkers, and the environment in 2002 in China were investigated. Of the 172 E. coli isolates, 39.0% carried oqxA, while only 4.1%, 2.9%, and 0.6% carried qnr (1 qnrB6 isolate, 5 qnrS1 isolates, and 1 qnrD isolate), qepA, and aac(6′)-Ib-cr, respectively. Among the 33 isolates from farmworkers, 10 (30.3%) were positive for oqxA. oqxAB was associated with IS26 and was carried on the 43- to 115-kb IncF transferable plasmid. Transconjugants carrying oqxAB showed 4- to 16-fold increases in the MICs of quinolones, 16- to 64-fold increases in the MICs of quinoxalines, 8- to 32-fold increases in the MICs of chloramphenicol and trimethoprim-sulfamethoxazole, and 4- to 8-fold increases in the MICs of florfenicol compared to the levels for the recipient. The pulsed-field gel electrophoresis (PFGE) analysis showed that the high levels of prevalence and dissemination of oqxAB in E. coli in animal farms were primarily due to the transmission of plasmids carrying oqxAB, although clonal transmission between human and swine E. coli isolates was observed. It is concluded that oqxAB was widespread in animal farms in China, which may be due to the overuse of quinoxalines in animals. This study warrants the prudent use of quinoxalines in food animals.
URI: http://hdl.handle.net/10397/21672
ISSN: 0066-4804
EISSN: 1098-6596
DOI: 10.1128/AAC.00139-10
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