Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21589
Title: Highly enantioselective diethylzinc addition to imines employing readily available N-monosubstituted amino alcohols
Authors: Zhang, HL
Zhang, XM
Gong, LZ
Mi, AQ
Cui, X
Jiang, YZ
Choi, MCK
Chan, ASC
Issue Date: 2002
Publisher: American Chemical Society
Source: Organic letters, 2002, v. 4, no. 8, p. 1399-1402 How to cite?
Journal: Organic letters 
Abstract: (Equation Presented) An easily accessible chiral ligand 3c, which promoted diethylzinc addition to imines with 96-98% ee, has been found by finely screening N,N-disubstituted and N-monosubstituted amino alcohols. N-Monosubstituted amino alcohols, on average, gave slightly higher enantioselectivities than their N,N-disubstituted analogues. These results imply that the restricted and rigid structure of amino alcohol is not the absolute requirement for the highly enantioselective dialkylzinc addition to diphenylphosphinoylimines.
URI: http://hdl.handle.net/10397/21589
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/ol025728u
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