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Title: Cordyceps sinensis mycelium extract induces human premyelocytic leukemia cell apoptosis through mitochondrion pathway
Authors: Zhang, QX
Wu, JY 
Keywords: Cordyceps sinensis
HL-60 cell
Cytochrome c
Bcl-2 proteins
Issue Date: 2007
Publisher: Society for Experimental Biology and Medicine
Source: Experimental biology and medicine, 2007, v. 232, no. 1, p. 52-57 How to cite?
Journal: Experimental biology and medicine 
Abstract: This study was to identify the signaling pathways for the induction of HL-60 cell apoptosis by Cordyceps sinensis mycelium extract (CSME). CSME at 25 μg/ml induced nuclear fragmentation and DNA degradation, two hallmark events of apoptosis, in the HL-60 cells within 12–24 hrs of treatment. Concomitantly, several major events in the mitochondrial signal pathway occurred, including the loss of MTP (ΔΨm), cytochrome c release into the cytoplasm, the decrease in Bcl-2 protein level, the translocation of Bax protein from cytoplasm into mitochondria, and the activation of caspase-2, −3, and −9, but caspase-8, the initiator caspase in the death receptor pathway, was not activated. These results suggest that CSME induces apoptosis in HL-60 cell through the mitochondrial pathway rather than the death receptor pathway.
ISSN: 1535-3702
EISSN: 1535-3699
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