Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21444
Title: Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus
Authors: Lam, PL
Lu, GL
Hon, KM
Lee, KW
Ho, CL
Wang, X
Tang, JCO 
Lam, KH
Wong, RSM
Kok, SHL
Bian, ZX
Li, H
Lee, KKH
Gambari, R
Chui, CH
Wong, WY
Issue Date: 2014
Publisher: Royal Society of Chemistry
Source: Dalton transactions : an international journal of inorganic chemistry, 2014, v. 43, no. 10, p. 3949-3957 How to cite?
Journal: Dalton transactions : an international journal of inorganic chemistry 
Abstract: A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.
URI: http://hdl.handle.net/10397/21444
ISSN: 1477-9226
EISSN: 1477-9234
DOI: 10.1039/c3dt52879k
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