Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21326
Title: Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice
Authors: Wang, YQ
Wang, SB
Ma, JL
Guo, J
Fang, Q
Sun, T
Zhuanga, Y
Wang, R
Keywords: Fever
Lipopolysaccharide (LPS)
Mice
Neuroinflammation
Neuropeptide FF (NPFF)
RF9
Issue Date: 2011
Publisher: Elsevier Science Inc
Source: Peptides, 2011, v. 32, no. 4, p. 702-706 How to cite?
Journal: Peptides 
Abstract: The endogenous opioid system has been found to be involved in the fever caused by lipopolysaccharide (LPS). Neuropeptide FF (NPFF, FLFQPQRF-NH 2) is an endogenous peptide known to modulate opioid activity, mainly in the central nervous system. Therefore, those data suggested a link between LPS-induced fever and NPFF systems. Using a model of acute neuroinflammation, we sought to determine the effects of NPFF systems on the fever induced by i.c.v. injection of LPS. Coinjected with different doses of NPFF (10 and 30 nmol), the fever of LPS (125 ng) was not modified. Interestingly, the selective NPFF receptors antagonist RF9 (30 nmol) injected into the third ventricle failed to induce significant effect, but it decreased the fever of LPS (125 ng) after cerebral administration in mice. These results suggest that NPFF receptors activation is required for LPS to produce fever. This interaction is the first evidence that NPFF systems participate in the control of acute neuroinflammation in conscious animals.
URI: http://hdl.handle.net/10397/21326
DOI: 10.1016/j.peptides.2010.12.001
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