Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21282
Title: Effect of ultrasound on acute inflammation of transected medial collateral ligaments
Authors: Leung, MC
Ng, GY 
Yip, KK
Keywords: Inflammation
Leukotriene B4
Ligaments, collateral
Prostaglandin E
Rehabilitation
Ultrasonography
Issue Date: 2004
Publisher: W.B. Saunders
Source: Archives of physical medicine and rehabilitation, 2004, v. 85, no. 6, p. 963-966 How to cite?
Journal: Archives of physical medicine and rehabilitation 
Abstract: Leung MC, Ng GY, Yip KK. Effect of ultrasound on acute inflammation of transected medial collateral ligaments. Arch Phys Med Rehabil 2004;85:963-6. Objective To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue injuries by measuring the levels of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). Design Randomized, case-control study. Setting Laboratory animal facility. Animals Thirty 3-month-old male Sprague-Dawley rats. Intervention Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5, 1.5, 2.3W/cm2). Main outcome measures Levels of PGE2 and LTB4. Results The levels of PGE2 and LTB4 were higher in all intensity subgroups that received 2.3W/cm2 intensity on postinjury day 2. On postinjury day 11, LTB4 was significantly decreased, but PGE2 was significantly increased. Conclusions Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.
URI: http://hdl.handle.net/10397/21282
ISSN: 0003-9993
EISSN: 1532-821X
DOI: 10.1016/j.apmr.2003.07.018
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