Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21269
Title: The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications
Authors: Liang, Z
Chan, CF
Liu, Y
Wong, WT 
Lee, CS
Law, GL 
Wong, KL
Issue Date: 2015
Publisher: Royal Society of Chemistry
Source: RSC advances, 2015, v. 5, no. 18, p. 13347-13356 How to cite?
Journal: RSC advances 
Abstract: Five water-soluble cyclen-based europium complexes incorporated with the pendant chelating chromophore, 2-methyl-4-(2-(4-propoxyphenyl)ethynyl)pyridine (L), as the antenna in different ratios have been synthesized and full structural characterization, photophysical measurement and in vitro biological studies were carried out. The antenna-to-metal ratios were 4 (Eu-4L), 3 (Eu-3L), 2 (1,4-disubstituted Eu-o-2L and 1,7-disubstituted Eu-p-2L) and 1 (Eu-1L). It was found that the definitive distinction between Eu-o-2L and Eu-p-2L could be interpreted from the emission spectra of Eu3+ at room and low temperatures. With all the results from subcellular stability testing (via titrations), in vitro imaging, cytotoxicity assays and cellular uptake profiles, Eu-4L with an overall +3 charge demonstrated subcellular localization towards lysosomes and was a potential compound for a selective time-resolved bio-labelling probe.
URI: http://hdl.handle.net/10397/21269
EISSN: 2046-2069
DOI: 10.1039/c4ra16536e
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