Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/21173
Title: Folic acid supplementation modifies beta-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice
Authors: Lam, TY
Seto, SW
Au, ALS
Poon, CCW
Li, RWS
Lam, HY
Lau, WS
Chan, SW
Ngai, SM
Leung, GPH
Lee, SMY
Tsui, SKW
Kwan, YW
Keywords: Beta-adrenoceptor
Lipolysis
Folic acid
Adipocytes
+db/ plus db mice
Issue Date: 2009
Publisher: Society for Experimental Biology and Medicine
Source: Experimental biology and medicine, 2009, v. 234, no. 9, p. 1047-1055 How to cite?
Journal: Experimental biology and medicine 
Abstract: The effects of folic acid (5.7 and 71 mu g/kg, 4 weeks) consumption on the beta-adrenoceptors (beta-ARs)-elicited lipolysis in vitro of the abdominal adipocytes of lean/control (+ml+db) and obese/diabetic (+dbl+db) mice (female) were investigated. beta-AR agonists (salbutamol, a beta(2)-AR agonist; BRL 37344 and CGP 12177, beta(3)-AR agonists; adrenaline, a beta-AR agonist-mediated lipolysis, beta(2)-, and beta(3-)ARs protein expression of the adipose tissues after folic acid consumption were evaluated. Our results demonstrate that a smaller magnitude of the basal (spontaneous) and the beta-AR agonists-triggered lipolysis was observed in +dbt+db mice, and folic acid supplementation (71 mu g/kg) resulted in an improvement of both the baseline and the beta-ARs-mediated lipolysis. In controls, a lower beta(2)- and beta(3)-ARs protein expression of the adipose tissues was detected in +dbl+db mice, compared to +ml+db mice. In both strains fed with folic acid (71 mu g/kg), a reduction of beta(2)-AR protein expression was observed compared to the respective controls. In +dbl+db mice, folic acid (5.7 and 71 mu g/kg) consumption caused a dose-dependent increase of beta(3)-AR protein expression compared to controls. We demonstrate that lipolysis elicited by beta-AR (beta(2)- and beta(3)-ARs) agonists was blunted in +dbl+db mice. Folic acid consumption has significant modulatory effects on beta-ARs protein expression and lipolysis.
URI: http://hdl.handle.net/10397/21173
ISSN: 1535-3702
EISSN: 1535-3699
DOI: 10.3181/0902-RM-44
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